Formulation and Evaluation of Solid Dispersion of Celecoxib
نویسندگان
چکیده
The aim of this study was to develop celecoxib (CLX) -polyvinylpyrrolidone (PVP) solid dispersion nanoparticles with and without surfactant using the supercritical antisolvent (SAS) process. effect different surfactants such as gelucire 44/14, poloxamer 188, 407, Ryoto sugar ester L1695, D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) on nanoparticle formation dissolution well oral absorption CLX -PVP K30 investigated. Spherical <300 nm in size were successfully developed SAS Analysis by differential scanning calorimetry powder X-ray diffraction showed that existed amorphous form within fabricated -PVPTPGS significantly enhanced vitro relative unprocessed form. area under concentration-time curve (AUC0 24 h) peak plasma concentration (Cmax) increased 4.6 5.7 times, respectively, -PVP-TPGS formulation. In addition, efficiency correlated vivo pharmacokinetic parameters. present demonstrated formulation process is a highly effective strategy for enhancing bioavailability poorly water-soluble CLX.
منابع مشابه
Formulation, characterization, and in vivo evaluation of celecoxib-PVP solid dispersion nanoparticles using supercritical antisolvent process.
The aim of this study was to develop celecoxib-polyvinylpyrrolidone (PVP) solid dispersion nanoparticles with and without surfactant using the supercritical antisolvent (SAS) process. The effect of different surfactants such as gelucire 44/14, poloxamer 188, poloxamer 407, Ryoto sugar ester L1695, and d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) on nanoparticle formation and dissolu...
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ژورنال
عنوان ژورنال: Asian Pacific journal of health sciences
سال: 2022
ISSN: ['2349-0659', '2350-0964']
DOI: https://doi.org/10.21276/apjhs.2022.9.4.62